Batol Haj Ebrahimi; Mohammad Kazemi Arab Abadi
Volume 20, Issue 3 , September and October 2013, , Pages 380-389
Abstract
Depression is a main complication in the developed and in developing countries. Studies showed that depression not only is a emotional disease but also affect the body. Immune system disordering is an important complication following depression. Studies showed that depression can induce immunological ...
Read More
Depression is a main complication in the developed and in developing countries. Studies showed that depression not only is a emotional disease but also affect the body. Immune system disordering is an important complication following depression. Studies showed that depression can induce immunological chronic inflammation, hence, lead to accelerate depression. Several molecules including JAK/STAT pathways and Toll like receptors, AIMII and NLRs play important roles in inducing chronic inflammation. It seems that the mentioned molecules can induce inflammation via cytokine production in depressed patients. Therefore, evaluation of cytokine patterns and cytokines producing pathways in depressed patients can help scientists to find the pathogenesis of depression. Thus, the aim of this review article was to collect recent information regarding cytokine patterns as well as the related molecules in inflammation in depression.
Mohammad Kazemi Arababadi; GhloamHossein Hasanshahi; Narges Yaghini; Reza Nosratabadi; Vahid Pooladvand; Ali Shamsizadeh
Volume 17, Issue 1 , March and April 2010, , Pages 33-38
Abstract
Background and Purpose: Cytokines are among the many immune system factors involved in diabetes pathogenesis. The level of cytokines expression such as IFN-y is varying in individuals and societies. Due to the fact that diabetes nephropathies are known as inflammatory disorders and the role of cytokines ...
Read More
Background and Purpose: Cytokines are among the many immune system factors involved in diabetes pathogenesis. The level of cytokines expression such as IFN-y is varying in individuals and societies. Due to the fact that diabetes nephropathies are known as inflammatory disorders and the role of cytokines especially IFN-g in the establishment of inflammations is well understood, the present study was aimed to examine serum level of IFN-y in type 2 diabetes patients with nephropathy complications. Material and methods: In this cross sectional descriptive study, serum samples were obtained from 100 type 2 diabetes patients with nephropathy and 100 healthy controls for the analysis of IFN-g serum level (eBiosense, ESP). Consent forms were also filled out by patients and healthy controls according to the rules and regulations of Zahedan Islamic Azad University Ethical Committee. The obtained data and questionnaires were analyzed in SPSS using ANOVA; p